Selected Publications (*corresponding author; ‡equally contributed)
41. Wang Z, Wu L, Gerasimenko M, Gillliland T, Rodriguez-Leyva I, Gunzler S, Donadio V, Liguori R, Xu B,* Zou WQ.* Seeding Activity of Skin Misfolded Tau as a Biomarker for Tauopathies. Under review. Mol Neurodegener. Manuscript ID: MOND-D-24-00104. 2024.
40. Zhang W, Orru CD, Foutz A, Ding M, Yuan J, Ali Shah SZ, Zhang J, Kotobelli K, Gerasimenko M, Gillliland T, Chen W, Tang M, Cohen M, Safar J, Xu B, Hong D, Cui L, Hoghson AG, Schonberger L, Tatsuika C, Chen SG, Greenlee JJ, Wang Z, Appleby B, Caughey B, Zou WQ. Large-Scale Validation of Skin Prion Seeding Activity as a Biomarker for Diagnosis of Prion Diseases. Acta Neuropathol. 2024, 147, 17.
39. Wu L, Arvai S, Wang SJ, Liu AJ,* Xu B.* Differential Diagnosis of Mild Cognitive Impairment of Alzheimer's Disease by Phospho-Tau181 Simoa Measurements with Matching Plasma and CSF. Front Mol Neurosci. 2023. 16, 1288930.
38. Xu B.* Fereshtehnejad SM,* Zeighami Y.* Prodromal Stage of Neurodegenerative Proteinopathies: From Bench to Bedside. Front Neurosci. 2023. 17, 1295344.
37. Wu L, Madhavan SS, Tan C, Xu B.* Hexameric Aggregation Nucleation Core Sequences and Diversity of Pathogenic Tau Strains. Pathogens. 2022, 11, 1559.
36. Wang Y, Wu Y, Wang AP, Wang AH, Alkhalidy H, Helm R, Zhang S, Ma H, Zhang Y, Gilbert ER, Xu B,* Liu D.* An Olive-Derived Elenolic Acid Stimulates Hormone Release from L-Cells and Exerts Potent Beneficial Metabolic Effects in Obese Diabetic Mice. Front Nutr. 2022, 9, 1051452.
35. Wu L, Gilyazova N, Ervin J, Wang SJ, Xu B*. Site-Specific Phospho-Tau Aggregation-Based Biomarker Discovery for AD Diagnosis and Differentiation. ACS Chem Neurosci. 2022, 13, 3281-3290.
Reported by ACS Newsroom, EurekAlert! by AAAS, UPI Health News, The Mirror, Medical News Today, Science Daily, etc over 32 news outlets (Altmetric Score 252).
34. Velander P,‡ Wu L,‡ Hildreth S, Vogelaar N, Mukhopadhyay B, Helm RF, Zhang S, Xu B*. Catechol-Containing Compounds are a Broad Class of Amyloid Inhibitors: Redox State is a Key Determinant of the Inhibitory Activities. Pharmacol Res. 2022, 184, 106409.
33. Wu L,‡ Wang Z,‡ Lad SP, Gilyazova N, Dougharty DT, Marcus M, Henderson F, Ray WK, Siedlak S, Li J, Helm RF, Zhu X, Bloom GS, Wang SJ, Zou W,* Xu B.* Selective Detection of Misfolded Tau from Post-Mortem Alzheimer's Disease Brains. Front Aging Neurosci. 2022, 14, 945875.
32. Wu L,‡ Velander P,‡ Brown AM, Wang Y, Liu D, Bevan DR, Zhang S, Xu B*. Rosmarinic Acid Potently Detoxifies Amylin Amyloid and Ameliorates Diabetic Pathology in a Transgenic Rat Model of Type 2 Diabetes. ACS Pharmacol Transl Sci. 2021, 4, 1322-1337.
Selected by ACS Pharmacol & Transl Sci in a virtual issue of "Diabetes and its Complications" as one of "the most exciting publications on the pharmacology of approved and investigational treatments of diabetes and its complications".
31. Wang Z, Manca M‡, Foutz A‡, Camacho MV‡, Raymond GJ, Race B, Orru CD, Yuan J, Shen P, Li B, Lang Y, Dang J, Adornato A, Williams K, Maurer NR, Gambetti P, Xu B, Surewicz W, Petersen RB, Dong X, Appleby BS, Caughey B, Cui L, Kong Q, Zou WQ. Early Preclinical Detection of Prions in the Skin of Prion-infected Animals. Nat. Commun. 2019, 10, 247 (1-11).
Reported by Science Daily, AAAS, Medical Research, Drug Target Review, and Case Western Reserve University School of Medicine News (Altmetric Score 94).
Before 2019 (Selected)
20. He L, Jiang Y, Liu K, Gomez-Murica V, Ma X, Torrecillas A, Wang L, Chen Q, Zhu X, Lesnefsky E, Gomez-Fernandez J, Xu B, Zhang S. Insights into the Impact of Membrane Anchor Moiety on the Biological Activities of Bivalent Compounds as Potential Neuroprotectants for Alzheimer's Disease. J. Med. Chem. 2018, 61, 777-790.
19. Wu L, Velander P, Liu D, Xu B*. Olive Component Oleuropein Promotes Beta-Cell Insulin Secretion and Protect Beta-Cells from Amylin Amyloid Induced Cytotoxicity. Biochemistry. 2017, 56, 5035-5039.
Reported by over 50 national and international news media (Altmetric Score 180).
Selected as Rapid Report for Timely Topics of Unusual Interest by Biochemistry
18. Velander P, Wu L, Henderson F, Zhang S, Bevan DR, Xu B*. Natural Product-Based Amyloid Inhibitors. Biochem. Pharmacol. 2017, 139, 40-55. (Invited Review)
Rated as a Highly Cited Paper (Total 184 citations by 3/9/2024)
17. Wu L & Xu B*. Using Thermogenic Beige Cells to Identify Biologically Active Small Molecules and Peptides. Methods Mol. Biol. 2017, "Thermogenic Fat". 1566, 203-212.
16. Zhang L, Qiu W, Crooke S, Li Y, Abid A, Xu B, Fung J, Finn MG, Lin F. Development of Autologous C5 Vaccine Nanoparticles to Reduce Intravascular Hemolysis in vivo. ACS Chem. Biol. 2017, 12, 539-547.
15. Velander P‡, Wu L‡, Ray WK, Helm RF, Xu B*. Amylin Amyloid Inhibition by Flavonoid Baicalein: Key Roles of its Vicinal Dihydroxyl Groups of the Catechol Moiety. Biochemistry. 2016, 55, 4255-4258. ‡ equal authorship.
Selected as Rapid Report for Timely Topics of Unusual Interest by Biochemistry
14. Zhai L‡, Wu L‡, Li F, Burnham RS, Pizarro JC, Xu B*. A Rapid Method for Refolding Cell Surface Receptors and Ligands. Sci. Rep. 2016, 6, 26482. ‡ equal authorship.
Recommended by Faculty of 1000 Prime
13. Wu L & Xu B*. Analysis of Protein Ligand-Receptor Binding by Photoaffinity Cross-Linking. Curr. Protoc. Protein Sci. 2015, 79, 19.26.1-19.26.14.
12. Watkins R‡, Wu L‡, Zhang C, Davis, RM, Xu B*. Natural Product-Based Nanomedicine: Recent Advances and Issues. Int. J. Nanomedicine, 2015, 10, 6055-6074. ‡ equal authorship.
Rated as a Highly Cited Paper (Total 393 citations by 2/23/2024)
11. Xu B* & Wu L. Analysis of Receptor-Ligand Binding by Photoaffinity Cross-linking. Science China Chemistry, Special issue on “The Frontiers of Chemical Biology and Synthesis” 2014, 57, 232-242.
10. Xu B, Pizarro JC, Holmes M, McBeth C, Groh V, Spies T, Strong RK. Crystal Structure of a γδ T Cell Receptor Specific for Human MHC Class I Homolog MICA. Proc. Natl. Acad. Sci. USA. 2011, 108, 2414-2419.
Fred Hutchinson VIDD News - Publication Spotlight
Rated as a Highly Cited Paper (Total 179 citations by 3/9/2024)
9. Yang Y, Petkova A, Huang K, Xu B, Hua Q, Ye I, Chu YC, Hu SQ, Phillips NB, Whittaker J, Ismail-Beigi F, Mackin RB, Katsoyannis PG, Tycko R, Weiss MA. An Achilles’ Heel in an Amyloidogenic Protein and its Repair. Insulin Fibrillation and Therapeutic Design. J. Biol. Chem. 2010, 285, 10806-10821.
8. Zhao M, Wan ZL, Whittaker L, Xu B, Phillips NB, Katsoyannis PG, Ismail-Beigi F, Whittaker J, Weiss MA. Design of an Insulin Analog with Enhanced Receptor-Binding Selectivity: Rationale, Structure, and Therapeutic Implications. J. Biol. Chem. 2009, 284, 32178-32187.
7. Xu B, Huang K, Chu YC, Hu SQ, Nakagawa S, Wang S, Wang R, Whittaker J, Katsoyannis PG, Weiss MA. Decoding the Cryptic Active Conformation of a Protein by Synthetic Photo-Scanning. Insulin Inserts a Detachable Arm between Receptor Domains. J. Biol. Chem. 2009, 284, 14597-14608.
Selected as "Paper Of The Week" by JBC
6. Hua QX, Xu B, Huang K, Hu SQ, Nakagawa S, Jia W, Wang S, Whittaker J, Katsoyannis PG, Weiss MA. Enhancing the Activity of a Protein by Stereospecific Unfolding: Conformational Life Cycle of Insulin and its Evolutionary Origins. J. Biol. Chem. 2009, 284, 14586-14596.
Selected as "Paper Of The Week" by JBC
5. Wan ZL‡ , Xu B‡ , Huang K, Chu YC, Li B, Nakagawa SH, Qu Y, Hu SQ, Katsoyannis PG, Weiss MA. Enhancing the Activity of Insulin at the Receptor Interface: Crystal Structure and Photo-Cross-Linking of A8 Analogues. Biochemistry. 2004, 43: 16119-16133. ‡ equal authorship.
4. Xu B, Hu SQ, Chu YC, Huang K, Nakagawa SH, Whittaker J, Katsoyannis PG, Weiss MA. Diabetes Associated Mutations in Insulin: Consecutive Residues in the B Chain Contact Distinct Domains of the Insulin Receptor. Biochemistry. 2004, 43, 8356-8372.
3. Huang K‡ , Xu B‡ , Hu SQ, Chu YC, Hua QX, Qu Y, Li B, Wang RY, Nakagawa SH, Jensen AM, Whittaker J, De Meyts P, Katsoyannis PG, and Weiss MA. How Insulin Binds: the B-chain α-helix Contacts the L1 betahelix of the Insulin Receptor. J. Mol. Biol. 2004, 341, 529-550. ‡ equal authorship.
2. Xu B., Hu S.Q., Chu Y.C., Wang S.H., Wang R.Y., Nakagawa S.H., Katsoyannis P.G., Weiss M.A. Diabetes-Associated Mutations in Human Insulin Identify Direct Hormone – Receptor Contacts. Diabetes. 2004, 53, 1599-1602.
1. Xu B, Hua QX, Nakagawa SH, Jia W, Chu YC, Katsoyannis PG, Weiss MA. Chrial Mutagenesis of Insulin's Hidden Receptor-Binding Surface: Structure of an allo-isoleucine(A2) Analogue. J. Mol. Biol. 2002, 316, 435-441.
41. Wang Z, Wu L, Gerasimenko M, Gillliland T, Rodriguez-Leyva I, Gunzler S, Donadio V, Liguori R, Xu B,* Zou WQ.* Seeding Activity of Skin Misfolded Tau as a Biomarker for Tauopathies. Under review. Mol Neurodegener. Manuscript ID: MOND-D-24-00104. 2024.
40. Zhang W, Orru CD, Foutz A, Ding M, Yuan J, Ali Shah SZ, Zhang J, Kotobelli K, Gerasimenko M, Gillliland T, Chen W, Tang M, Cohen M, Safar J, Xu B, Hong D, Cui L, Hoghson AG, Schonberger L, Tatsuika C, Chen SG, Greenlee JJ, Wang Z, Appleby B, Caughey B, Zou WQ. Large-Scale Validation of Skin Prion Seeding Activity as a Biomarker for Diagnosis of Prion Diseases. Acta Neuropathol. 2024, 147, 17.
39. Wu L, Arvai S, Wang SJ, Liu AJ,* Xu B.* Differential Diagnosis of Mild Cognitive Impairment of Alzheimer's Disease by Phospho-Tau181 Simoa Measurements with Matching Plasma and CSF. Front Mol Neurosci. 2023. 16, 1288930.
38. Xu B.* Fereshtehnejad SM,* Zeighami Y.* Prodromal Stage of Neurodegenerative Proteinopathies: From Bench to Bedside. Front Neurosci. 2023. 17, 1295344.
37. Wu L, Madhavan SS, Tan C, Xu B.* Hexameric Aggregation Nucleation Core Sequences and Diversity of Pathogenic Tau Strains. Pathogens. 2022, 11, 1559.
36. Wang Y, Wu Y, Wang AP, Wang AH, Alkhalidy H, Helm R, Zhang S, Ma H, Zhang Y, Gilbert ER, Xu B,* Liu D.* An Olive-Derived Elenolic Acid Stimulates Hormone Release from L-Cells and Exerts Potent Beneficial Metabolic Effects in Obese Diabetic Mice. Front Nutr. 2022, 9, 1051452.
35. Wu L, Gilyazova N, Ervin J, Wang SJ, Xu B*. Site-Specific Phospho-Tau Aggregation-Based Biomarker Discovery for AD Diagnosis and Differentiation. ACS Chem Neurosci. 2022, 13, 3281-3290.
Reported by ACS Newsroom, EurekAlert! by AAAS, UPI Health News, The Mirror, Medical News Today, Science Daily, etc over 32 news outlets (Altmetric Score 252).
34. Velander P,‡ Wu L,‡ Hildreth S, Vogelaar N, Mukhopadhyay B, Helm RF, Zhang S, Xu B*. Catechol-Containing Compounds are a Broad Class of Amyloid Inhibitors: Redox State is a Key Determinant of the Inhibitory Activities. Pharmacol Res. 2022, 184, 106409.
33. Wu L,‡ Wang Z,‡ Lad SP, Gilyazova N, Dougharty DT, Marcus M, Henderson F, Ray WK, Siedlak S, Li J, Helm RF, Zhu X, Bloom GS, Wang SJ, Zou W,* Xu B.* Selective Detection of Misfolded Tau from Post-Mortem Alzheimer's Disease Brains. Front Aging Neurosci. 2022, 14, 945875.
32. Wu L,‡ Velander P,‡ Brown AM, Wang Y, Liu D, Bevan DR, Zhang S, Xu B*. Rosmarinic Acid Potently Detoxifies Amylin Amyloid and Ameliorates Diabetic Pathology in a Transgenic Rat Model of Type 2 Diabetes. ACS Pharmacol Transl Sci. 2021, 4, 1322-1337.
Selected by ACS Pharmacol & Transl Sci in a virtual issue of "Diabetes and its Complications" as one of "the most exciting publications on the pharmacology of approved and investigational treatments of diabetes and its complications".
31. Wang Z, Manca M‡, Foutz A‡, Camacho MV‡, Raymond GJ, Race B, Orru CD, Yuan J, Shen P, Li B, Lang Y, Dang J, Adornato A, Williams K, Maurer NR, Gambetti P, Xu B, Surewicz W, Petersen RB, Dong X, Appleby BS, Caughey B, Cui L, Kong Q, Zou WQ. Early Preclinical Detection of Prions in the Skin of Prion-infected Animals. Nat. Commun. 2019, 10, 247 (1-11).
Reported by Science Daily, AAAS, Medical Research, Drug Target Review, and Case Western Reserve University School of Medicine News (Altmetric Score 94).
Before 2019 (Selected)
20. He L, Jiang Y, Liu K, Gomez-Murica V, Ma X, Torrecillas A, Wang L, Chen Q, Zhu X, Lesnefsky E, Gomez-Fernandez J, Xu B, Zhang S. Insights into the Impact of Membrane Anchor Moiety on the Biological Activities of Bivalent Compounds as Potential Neuroprotectants for Alzheimer's Disease. J. Med. Chem. 2018, 61, 777-790.
19. Wu L, Velander P, Liu D, Xu B*. Olive Component Oleuropein Promotes Beta-Cell Insulin Secretion and Protect Beta-Cells from Amylin Amyloid Induced Cytotoxicity. Biochemistry. 2017, 56, 5035-5039.
Reported by over 50 national and international news media (Altmetric Score 180).
Selected as Rapid Report for Timely Topics of Unusual Interest by Biochemistry
18. Velander P, Wu L, Henderson F, Zhang S, Bevan DR, Xu B*. Natural Product-Based Amyloid Inhibitors. Biochem. Pharmacol. 2017, 139, 40-55. (Invited Review)
Rated as a Highly Cited Paper (Total 184 citations by 3/9/2024)
17. Wu L & Xu B*. Using Thermogenic Beige Cells to Identify Biologically Active Small Molecules and Peptides. Methods Mol. Biol. 2017, "Thermogenic Fat". 1566, 203-212.
16. Zhang L, Qiu W, Crooke S, Li Y, Abid A, Xu B, Fung J, Finn MG, Lin F. Development of Autologous C5 Vaccine Nanoparticles to Reduce Intravascular Hemolysis in vivo. ACS Chem. Biol. 2017, 12, 539-547.
15. Velander P‡, Wu L‡, Ray WK, Helm RF, Xu B*. Amylin Amyloid Inhibition by Flavonoid Baicalein: Key Roles of its Vicinal Dihydroxyl Groups of the Catechol Moiety. Biochemistry. 2016, 55, 4255-4258. ‡ equal authorship.
Selected as Rapid Report for Timely Topics of Unusual Interest by Biochemistry
14. Zhai L‡, Wu L‡, Li F, Burnham RS, Pizarro JC, Xu B*. A Rapid Method for Refolding Cell Surface Receptors and Ligands. Sci. Rep. 2016, 6, 26482. ‡ equal authorship.
Recommended by Faculty of 1000 Prime
13. Wu L & Xu B*. Analysis of Protein Ligand-Receptor Binding by Photoaffinity Cross-Linking. Curr. Protoc. Protein Sci. 2015, 79, 19.26.1-19.26.14.
12. Watkins R‡, Wu L‡, Zhang C, Davis, RM, Xu B*. Natural Product-Based Nanomedicine: Recent Advances and Issues. Int. J. Nanomedicine, 2015, 10, 6055-6074. ‡ equal authorship.
Rated as a Highly Cited Paper (Total 393 citations by 2/23/2024)
11. Xu B* & Wu L. Analysis of Receptor-Ligand Binding by Photoaffinity Cross-linking. Science China Chemistry, Special issue on “The Frontiers of Chemical Biology and Synthesis” 2014, 57, 232-242.
10. Xu B, Pizarro JC, Holmes M, McBeth C, Groh V, Spies T, Strong RK. Crystal Structure of a γδ T Cell Receptor Specific for Human MHC Class I Homolog MICA. Proc. Natl. Acad. Sci. USA. 2011, 108, 2414-2419.
Fred Hutchinson VIDD News - Publication Spotlight
Rated as a Highly Cited Paper (Total 179 citations by 3/9/2024)
9. Yang Y, Petkova A, Huang K, Xu B, Hua Q, Ye I, Chu YC, Hu SQ, Phillips NB, Whittaker J, Ismail-Beigi F, Mackin RB, Katsoyannis PG, Tycko R, Weiss MA. An Achilles’ Heel in an Amyloidogenic Protein and its Repair. Insulin Fibrillation and Therapeutic Design. J. Biol. Chem. 2010, 285, 10806-10821.
8. Zhao M, Wan ZL, Whittaker L, Xu B, Phillips NB, Katsoyannis PG, Ismail-Beigi F, Whittaker J, Weiss MA. Design of an Insulin Analog with Enhanced Receptor-Binding Selectivity: Rationale, Structure, and Therapeutic Implications. J. Biol. Chem. 2009, 284, 32178-32187.
7. Xu B, Huang K, Chu YC, Hu SQ, Nakagawa S, Wang S, Wang R, Whittaker J, Katsoyannis PG, Weiss MA. Decoding the Cryptic Active Conformation of a Protein by Synthetic Photo-Scanning. Insulin Inserts a Detachable Arm between Receptor Domains. J. Biol. Chem. 2009, 284, 14597-14608.
Selected as "Paper Of The Week" by JBC
6. Hua QX, Xu B, Huang K, Hu SQ, Nakagawa S, Jia W, Wang S, Whittaker J, Katsoyannis PG, Weiss MA. Enhancing the Activity of a Protein by Stereospecific Unfolding: Conformational Life Cycle of Insulin and its Evolutionary Origins. J. Biol. Chem. 2009, 284, 14586-14596.
Selected as "Paper Of The Week" by JBC
5. Wan ZL‡ , Xu B‡ , Huang K, Chu YC, Li B, Nakagawa SH, Qu Y, Hu SQ, Katsoyannis PG, Weiss MA. Enhancing the Activity of Insulin at the Receptor Interface: Crystal Structure and Photo-Cross-Linking of A8 Analogues. Biochemistry. 2004, 43: 16119-16133. ‡ equal authorship.
4. Xu B, Hu SQ, Chu YC, Huang K, Nakagawa SH, Whittaker J, Katsoyannis PG, Weiss MA. Diabetes Associated Mutations in Insulin: Consecutive Residues in the B Chain Contact Distinct Domains of the Insulin Receptor. Biochemistry. 2004, 43, 8356-8372.
3. Huang K‡ , Xu B‡ , Hu SQ, Chu YC, Hua QX, Qu Y, Li B, Wang RY, Nakagawa SH, Jensen AM, Whittaker J, De Meyts P, Katsoyannis PG, and Weiss MA. How Insulin Binds: the B-chain α-helix Contacts the L1 betahelix of the Insulin Receptor. J. Mol. Biol. 2004, 341, 529-550. ‡ equal authorship.
2. Xu B., Hu S.Q., Chu Y.C., Wang S.H., Wang R.Y., Nakagawa S.H., Katsoyannis P.G., Weiss M.A. Diabetes-Associated Mutations in Human Insulin Identify Direct Hormone – Receptor Contacts. Diabetes. 2004, 53, 1599-1602.
1. Xu B, Hua QX, Nakagawa SH, Jia W, Chu YC, Katsoyannis PG, Weiss MA. Chrial Mutagenesis of Insulin's Hidden Receptor-Binding Surface: Structure of an allo-isoleucine(A2) Analogue. J. Mol. Biol. 2002, 316, 435-441.