3/29/2024: Nada and Bria both presented via zoom at Duke-UNC Alzheimer's Disease Research Center IDEAS forum on March 28, 2024 at 4 - 5 pm. Well done, Nada and Bria.
3/15/2024: Bin served as a panelist on NIH Study Section "Global Brain and Nervous System Disorders Research Across the Lifespan".
2/15/2024: Ling's R03 proposal on new biomarkers for early AD diagnosis was awarded by National Institute on Aging of NIH. This special small research grant aims to train and develop next generation of AD and ADRD researchers.
1/17/2024: A skin-based neurodegenerative disease biomarker study with Wen-Quan Zou, MD, PhD's team at Case Western Reserve University was published today!
12/10/2023: Our new study on early disease diagnosis "Differential diagnosis of mild cognitive impairment of Alzheimer's disease by Simoa p-tau181 measurements with matching plasma and CSF" has been accepted for publication in Frontiers in Molecular Neuroscience. It's a wonderful collaboration with Andy Liu, MD and Jerry Wang, MD, PhD from Departments of Neurology and Pathology at Duke University Medical Center.
11/21/2023: Congratulations to Hibat for successfully defended her thesis titled "Identification of A New Site-Specific Phospho-Tau Biomarker for Alzheimer's Disease Diagnosis and Differentiation".
11/6/2023: Collaborative NIH R25 training grant application titled "Pipeline in Aging Research Career Training (PACT)" (Site PI: Prof. Andy Li) with faculties from Georgetown University received fundable impact score of 21 from National Institute on Aging.
10/2/2023: Collaborative editorial/mini-review with Dr. Fareshtehnejad from Karolinska Institutet and Dr. Zeighami from University of Toronto has been published in the Frontiers in Neuroscience.
9/23/2023: Xu Lab members visited our sister institute, Biomanufacturing Training and Education Center (BTEC) at North Carolina State University. Dr. Xu gave a seminar titled "Ultrasensitive detection technology enabled biomarker discovery for Alzheimer's early diagnosis".
9/7/2023: Congratulations to Fares, a senior in Pharmaceutical Sciences and an intern in Biogen, who was chosen as the Student of the Month for his academic achievements!
6/20/2023: Xu Lab won NC Biotech Center Translational Research Grant titled "Misfolded Tau-Based Biomarkers for diagnosing and Differentiating AD and ADRD", in collaboration with Profs. Jerry Wang and Andy Liu at Duke University Medical Center.
5/21/2023: Xu Lab members attended Duke/UNC Alzheimer's Disease Research Center 2nd Annual Symposium at UNC Pembroke from 5/18-5/19. Drs. Xu and Wu each gave a talk on AD biomarker discovery. Hibat, Nada and Fares each presented a poster on AD biomarker or drug discovery.
4/15/2023: Dr. Xu is invited to be a Medical Advisory Board member for the Diabetes Action Research and Education Foundation.
3/26/2023: Both Hibat and Nada presented at NCCU Annual Graduate Research Symposium. Hibat gave a short oral talk titled "Identification of new site-specific phospho-tau biomarkers for Alzheimer's disease diagnosis and differentiation" and won first place in graduate student presentations. Nada gave a poster presentation titled "Identification of new tau aggregation inhibitors". Well done, Hibat and Nada!
3/15/2023: Congratulation to Fares for landing an internship opportunity in Fall 2023 in Biogen Pharmaceutical in the Research Triangle Park, NC.
1/2/2023: Thanks for joint BRITE funds and NIH Instrument funds, a dedicated ultrasensitive single molecular array SR-X Biomarker Detection System was purchased and installed in our laboratory!
12/14/2022: Our manuscript titled "Hexameric Aggregation Nucleation Core Sequences and Diversity of Pathogenic Tau Strains" has been published in the journal of Pathogens. Congratulations to former undergraduate students from Virginia Tech, Sid Madhavan and Christopher Tan, for significant effort and contribution!
12/1/2022: Sabin successfully Defended his Master's Thesis in Pharmaceutical Sciences titled "Parallel Screening Identifies Tau Aggregation Inhibitors" on Nov. 16, 2022. Sabin Khatiwada was also highlighted as a Student of the Month for academics and research achievements at BRITE Institute. Congratulations, Sabin!
11/9/2022: Our work on "Site-specific phospho-tau aggregation-based biomarker discovery for AD diagnosis and differentiation" published in ACS Chemical Neuroscience is reported by over 30 news outlets, including ACS Newsroom, EurekAlert! by AAAS, UPI Health News, The Mirror, Medical News Today, and Science Daily.
10/11/2022: Our collaborative work on "An olive-derived elenolic acid stimulate hormone release from L-cells and exert potential beneficial metabolic effects in obese diabetic mice" has been accepted for publication in Frontiers in Nutrition. Congratulations to Dr. Yao Wang for her thesis work and collaborations with Prof. Dongmin Liu at Virginia Tech and Prof. Shijun Zhang at Virginia Commonwealth University.
10/3/2022: Our manuscript "Site-specific phospho-tau aggregation-based biomarker discovery for Ad diagnosis and differentiation" has been accepted for publication in ACS Chemical Neuroscience. Congratulations to Ling, Nailya and collaboration with Prof. Jerry Wang's group from Duke.
9/28/2022: Welcome new lab member Nada Elbarbary! Nada, who graduated with a major in clinical pharmacy from Cairo University, Egypt, is a first year graduate student in Pharmaceutical Sciences.
9/28/2022: Welcome new lab member Nada Elbarbary! Nada, who graduated with a major in clinical pharmacy from Cairo University, Egypt, is a first year graduate student in Pharmaceutical Sciences.
8/17/2022: Our manuscript "Catechol-Containing Compounds are a Broad Class of Protein Aggregation Inhibitors: Redox State is a Key Determinant of the Inhibitory Activities" has been accepted for publication in Pharmacological Research (Elsevier). Congratulations to Dr. Paul Velander, first PhD student from the lab and Dr. Ling Wu, and our collaborators from Virginia.
8/12/2022: Dr. Xu is invited to be a member of the Duke/UNC Alzheimer's Disease Research Center Research and Education Core's first Advisory Committee.
7/23/2022: Congratulations to Hibat Gindeel for being selected as a GLIAL Scholarship in Neuroscience Thesis Research supported by a NIH R25 trainee grant!
6/21/2022: Our manuscript titled "Selective Detection of Misfolded Tau from Postmortem Alzheimer's Disease Brains" has been accepted for publication in the journal of Frontiers in Aging Neuroscience. Congratulations to Ling, a long list of outstanding students from Virginia Tech and our collaborator Dr. Wenquan Zou's lab from Case Western Reserve University.
5/25/2022: Dr. Xu will serve as a co-editor with Dr. Schlossmacher at the Ottawa Hospital and the University of Ottawa and Dr. Sayed-Mohammad Fereshtehnejad at Karolinska Institutet for the journal of Frontiers in Neuroscience on translational research topic "Prodromal Stage of Neurodegenerative Proteinopathies: From Bench to Bedside".
5/25/2022: Dr. Xu will serve as a co-editor with Dr. Schlossmacher at the Ottawa Hospital and the University of Ottawa and Dr. Sayed-Mohammad Fereshtehnejad at Karolinska Institutet for the journal of Frontiers in Neuroscience on translational research topic "Prodromal Stage of Neurodegenerative Proteinopathies: From Bench to Bedside".
4/2/2022: Congratulations to Ling to be selected as the inaugural cohort of REC Scholars by NIH designated Duke/UNC Alzheimer's Disease Research Center!
4/2/2022: Congratulations to Ling to be selected as the inaugural cohort of REC Scholars by NIH designated Duke/UNC Alzheimer's Disease Research Center!
9/25/2021: Excited to win first R01 award (totaling $3.8M) from NIH on "Skin biomarkers for diagnosing and characterizing AD and ADRD". Great collaborative efforts with researchers and clinicians from CWRU, NYU, Emory, and Iowa State.
9/25/2021: Excited to win first R01 award (totaling $3.8M) from NIH on "Skin biomarkers for diagnosing and characterizing AD and ADRD". Great collaborative efforts with researchers and clinicians from CWRU, NYU, Emory, and Iowa State.
9/8/2021: Dr. Xu gave an invited talk titled "Small Molecule modifiers of Toxic Protein Aggregation in Aging and Neurodegenerative Diseases" at the NO_Age and NO_AD Seminar Series hosted by Prof. Evandro Fang of the University of Oslo.
9/8/2021: Dr. Xu gave an invited talk titled "Small Molecule modifiers of Toxic Protein Aggregation in Aging and Neurodegenerative Diseases" at the NO_Age and NO_AD Seminar Series hosted by Prof. Evandro Fang of the University of Oslo.
7/2/2021: Our manuscript titled "Rosmarinic Acid Potently Detoxifies Amylin Amyloid and Ameliorates Diabetic Pathology in a Transgenic Rat Model of Type 2 Diabetes" has been accepted for publication. Congratulations to Ling and formal graduate student, Paul!
7/2/2021: Our manuscript titled "Rosmarinic Acid Potently Detoxifies Amylin Amyloid and Ameliorates Diabetic Pathology in a Transgenic Rat Model of Type 2 Diabetes" has been accepted for publication. Congratulations to Ling and formal graduate student, Paul!
6/5/2021: In collaboration with Prof. Jerry Wang's lab at Duke Pathology & Neurology, our project "Develoment of CSF-based ultrasensitive tests for Alzheimer's diagnosis and predicting disease progression" was funded by Duke Clinical & Translational Science Institute (CTSI).
5/25/2021: Dr. Xu gave an invited talk at the "Molecular Basis of Proteinopathies" Zoominar series hosted by Prof. Ayyalusamy Ramamoorthy of the University of Michigan.
5/25/2021: Dr. Xu gave an invited talk at the "Molecular Basis of Proteinopathies" Zoominar series hosted by Prof. Ayyalusamy Ramamoorthy of the University of Michigan.
5/20/2021: Welcome new lab member Bria Yates! Bria is a graduate student in the Pharmaceutical Sciences Master Program.
5/15/2021: Dr. Xu hosted first NCCU Behavioral Core training workshop on May 11 and May 12 on Stoelting behavioral equipment.
5/15/2021: Dr. Xu hosted first NCCU Behavioral Core training workshop on May 11 and May 12 on Stoelting behavioral equipment.
4/15/2021: Welcome new lab member Sabin Khatiwada! Sabin is a graduate student in the Pharmaceutical Sciences Master Program.
4/15/2021: Welcome new lab member Sabin Khatiwada! Sabin is a graduate student in the Pharmaceutical Sciences Master Program.
3/2/2021: Our Multi-PI R01 proposal "Skin Biomarkers for Diagnosing and Characterizing AD and ADRD" with Prof. Wenquan Zou's group and additional partner groups scored 9.0 percentile by NIH Study Section! We look forward to this highly innovative study.
3/2/2021: Our Multi-PI R01 proposal "Skin Biomarkers for Diagnosing and Characterizing AD and ADRD" with Prof. Wenquan Zou's group and additional partner groups scored 9.0 percentile by NIH Study Section! We look forward to this highly innovative study.
2/20/2021: Dr. Xu is invited to give a virtual talk at the "Molecular Basis of Proteinopathies" seminar series at the University of Michigan hosted by Prof. Ayyalusamy Ramamoorthy. The seminar is scheduled on May 22, 2021 at 10:45-11:30 am on "Small Molecule Modifiers of Toxic Protein Aggregation in Neurodegenerative and Aging Diseases".
2/20/2021: Dr. Xu is invited to give a virtual talk at the "Molecular Basis of Proteinopathies" seminar series at the University of Michigan hosted by Prof. Ayyalusamy Ramamoorthy. The seminar is scheduled on May 22, 2021 at 10:45-11:30 am on "Small Molecule Modifiers of Toxic Protein Aggregation in Neurodegenerative and Aging Diseases".
1/10/2021: Dr. Ling Wu relocated from Virginia Tech to the BRITE Research Institute as a Research Assistant Professor. Congratulations to Ling!
1/10/2021: Dr. Ling Wu relocated from Virginia Tech to the BRITE Research Institute as a Research Assistant Professor. Congratulations to Ling!
10/15/2020: Xu Lab was awarded a new grant on "Novel functions of rosmarinic acid and its analog as diabetes prevention nutraceuticals: in vivo efficacy studies" from Diabetes Action Research and Education Foundation (DAREF). We thank DAREF's strong support!
10/15/2020: Xu Lab was awarded a new grant on "Novel functions of rosmarinic acid and its analog as diabetes prevention nutraceuticals: in vivo efficacy studies" from Diabetes Action Research and Education Foundation (DAREF). We thank DAREF's strong support!
9/28/2020: Dr. Xu was selected to serve as an Editorial Board Member for the journal of Frontiers in Aging Neuroscience.
9/28/2020: Dr. Xu was selected to serve as an Editorial Board Member for the journal of Frontiers in Aging Neuroscience.
9/17/2020: Dr. Paul Velander, first Ph.D. student in Xu Laboratory, landed a faculty position of assistant professor in biochemistry education at the University of Nebraska Lincoln. Congratulations, Paul! That's an extraordinary transition from a formal "Big Ten" basketball player to a professor!!
9/17/2020: Dr. Paul Velander, first Ph.D. student in Xu Laboratory, landed a faculty position of assistant professor in biochemistry education at the University of Nebraska Lincoln. Congratulations, Paul! That's an extraordinary transition from a formal "Big Ten" basketball player to a professor!!
5/10/2020: Dr. Xu was selected to serve as an Editorial Board Member (reviewing editor) for the journal of Frontiers in Neuroscience, Neurodegeneration Section.
5/10/2020: Dr. Xu was selected to serve as an Editorial Board Member (reviewing editor) for the journal of Frontiers in Neuroscience, Neurodegeneration Section.
4/18/2020: Dr. Xu at BRITE institute and a faculty colleague from Biomedical and Biotechnology Research Institute (BBRI) initiated a neurobehavioral phenotype core facility for animal behavioral tests in learning and memory, motor functions, sensorimotor tests, in vivo drug efficacy evaluation etc. We are open for academic collaborations in neurodegeneration and drug discovery.
4/18/2020: Dr. Xu at BRITE institute and a faculty colleague from Biomedical and Biotechnology Research Institute (BBRI) initiated a neurobehavioral phenotype core facility for animal behavioral tests in learning and memory, motor functions, sensorimotor tests, in vivo drug efficacy evaluation etc. We are open for academic collaborations in neurodegeneration and drug discovery.
3/9/2020: Xu lab NIH R03 grant on "Pilot Study on Novel Compounds for the Prevention of Aging-Related Diabetic Hyperamylinemia" renewed.
3/9/2020: Xu lab NIH R03 grant on "Pilot Study on Novel Compounds for the Prevention of Aging-Related Diabetic Hyperamylinemia" renewed.
2/18/2020: Congratulations to Sid for being admitted to Buck Institute for Research on Aging and University of Southern California joint PhD program and for winning a Provost Fellowship!
1/3/2020: Our first tau paper titled "Human tau isoform aggregation and selective detection of misfolded tau from post-mortem Alzheimer's disease brains" has been published online as preprint at Cold Harbor Spring Laboratory preprint server bioRxiv.
1/3/2020: Our first tau paper titled "Human tau isoform aggregation and selective detection of misfolded tau from post-mortem Alzheimer's disease brains" has been published online as preprint at Cold Harbor Spring Laboratory preprint server bioRxiv.
12/17/2019: Congratulations to Christopher for being admitted to Virginia Commonwealth University Medical School M.D. program.
12/17/2019: Congratulations to Christopher for being admitted to Virginia Commonwealth University Medical School M.D. program.
12/15/2019: Congratulations to Sid for graduation from Virginia Tech Clinical Neuroscience Program.
12/15/2019: Congratulations to Sid for graduation from Virginia Tech Clinical Neuroscience Program.
10/8/2019: Dr. Xu is a selected speaker at the Cold Spring Harbor Asia meeting in Chemical Biology and Drug Discovery. The title of his talk is "Discovery and mechanisms of natural product-based protein aggregation small molecule inhibitors".
10/8/2019: Dr. Xu is a selected speaker at the Cold Spring Harbor Asia meeting in Chemical Biology and Drug Discovery. The title of his talk is "Discovery and mechanisms of natural product-based protein aggregation small molecule inhibitors".
8/22/2019: Dr. Xu has been selected to serve as an Editorial Board Member for the journal of Current Diabetes Reviews (Bentham Science Press).
8/22/2019: Dr. Xu has been selected to serve as an Editorial Board Member for the journal of Current Diabetes Reviews (Bentham Science Press).
8/14/2019: Xu Lab was awarded a new research grant titled "Novel functions of rosmarinic acid and its analog as diabetes-prevention nutraceuticals: in vivo efficacy studies" from Diabetes Action Research and Education Foundation (DAREF).
8/14/2019: Xu Lab was awarded a new research grant titled "Novel functions of rosmarinic acid and its analog as diabetes-prevention nutraceuticals: in vivo efficacy studies" from Diabetes Action Research and Education Foundation (DAREF).
5/7/2019: Dr. Xu is an invited speaker at the 2019 Southeastern & Greater Atlanta Chemical Biology Symposium.
5/7/2019: Dr. Xu is an invited speaker at the 2019 Southeastern & Greater Atlanta Chemical Biology Symposium.
5/1/2019: Congratulations to Sid for winning research fellowship enrichment grant from Virginia Tech Honors College!
4/25/2019: Congratulations to Darren for winning Thomas O. Sitz Scholarship, provided by the Virginia Academy of Sciences Sitz Fund!
4/14/2019: Xu lab hosted VTLSS seminar speaker, Prof. Wen-Quan Zou from Case Western Reserve University School of Medicine on 4/12/2019. Dr. Zou gave an excellent talk on highly innovative work on skin-based biomarker discoveries in neurodegenerative diseases!
4/14/2019: Xu lab hosted VTLSS seminar speaker, Prof. Wen-Quan Zou from Case Western Reserve University School of Medicine on 4/12/2019. Dr. Zou gave an excellent talk on highly innovative work on skin-based biomarker discoveries in neurodegenerative diseases!
4/2/2019: Xu lab was part of a team with Prof. Wenquan Zou's lab at Case Western Reserve University School of Medicine to win a grant award titled "Skin biomarkers as diagnostic tests across neurodegenerative diseases" from Alzheimer's Association for Biomarker Across Neurodegenerative Diseases (BAND) program.
4/2/2019: Xu lab was part of a team with Prof. Wenquan Zou's lab at Case Western Reserve University School of Medicine to win a grant award titled "Skin biomarkers as diagnostic tests across neurodegenerative diseases" from Alzheimer's Association for Biomarker Across Neurodegenerative Diseases (BAND) program.
3/22/2019: Congratulations to Sid for winning an ACC Creativity and Innovation Grant to perform summer research on Alzheimer's research!
3/2/2019: Dr. Xu gave a seminar in the Department of Pharmaceutical Sciences at the Biomanufacturing Research Institute and Technology Enterprise (BRITE) in Durham, NC on "Discovery and Mechanisms of Novel Bioactive Small Molecules for Treating Diabetes and Neurodegeneration".
3/2/2019: Dr. Xu gave a seminar in the Department of Pharmaceutical Sciences at the Biomanufacturing Research Institute and Technology Enterprise (BRITE) in Durham, NC on "Discovery and Mechanisms of Novel Bioactive Small Molecules for Treating Diabetes and Neurodegeneration".
2/14/2019: Dr. Xu gave a seminar in the Department of Chemistry at the University of the Pacific in Stockton, CA on "Chemical Biology of Protein Aggregation: Small Molecule Inhibitor Discovery and Mechanisms".
1/31/2019: Xu lab was awarded first NIH grant "Pilot Study on Novel Compounds for the Prevention of Aging-Related Diabetic Hyperamylinemia".
12/8/2018: Great to be part of a large collaborating team with Prof. Wenquan Zou at Case Western Reserve University for work "Early preclinical detection of prions in the skin of prion-infected animals" accepted for publication in Nature Communications.
12/8/2018: Great to be part of a large collaborating team with Prof. Wenquan Zou at Case Western Reserve University for work "Early preclinical detection of prions in the skin of prion-infected animals" accepted for publication in Nature Communications.
11/9/2018: Sid and Darren won a poster presentation award at the Virginia Tech Center for Drug Discovery Annual Poster Session. The title of the poster is "Aggregation of Human Isoform Proteins in Alzheimer's Disease". Well done!
11/9/2018: Sid and Darren won a poster presentation award at the Virginia Tech Center for Drug Discovery Annual Poster Session. The title of the poster is "Aggregation of Human Isoform Proteins in Alzheimer's Disease". Well done!
8/25/2018: Alisa Bondar, a BCHM junior, joined the lab. Welcome, Alisa!
8/25/2018: Alisa Bondar, a BCHM junior, joined the lab. Welcome, Alisa!
8/10/2018: Xu Lab was awarded a research grant titled "Novel functions of oleuropein and rosmarinic acid as diabetes-prevention nutraceuticals: in vivo efficacy studies" from Diabetes Action Research and Education Foundation (DAREF).
8/10/2018: Xu Lab was awarded a research grant titled "Novel functions of oleuropein and rosmarinic acid as diabetes-prevention nutraceuticals: in vivo efficacy studies" from Diabetes Action Research and Education Foundation (DAREF).
7/27/2018: Darren, Sid, and Christopher took part in Virginia Tech Annual Undergraduate Summer Research Symposium held at the Goodwin Hall. They each presented a poster on "Aggregation of tau proteins in Alzheimer's disease: I. Human tau isoforms; and II. A truncation mutagenesis approach".
7/27/2018: Darren, Sid, and Christopher took part in Virginia Tech Annual Undergraduate Summer Research Symposium held at the Goodwin Hall. They each presented a poster on "Aggregation of tau proteins in Alzheimer's disease: I. Human tau isoforms; and II. A truncation mutagenesis approach".
7/13/2018: Shradha took a job offer from Proneurotech in San Francisco. Congratulations!
7/13/2018: Shradha took a job offer from Proneurotech in San Francisco. Congratulations!
5/14/2018: Sid Madhavan, a rising junior of Clinical Neuroscience major at Virginia Tech, joined the lab. Welcome, Sid! Sid will also perform a CHRB-funded undergraduate research fellowship in the lab this summer.
5/14/2018: Sid Madhavan, a rising junior of Clinical Neuroscience major at Virginia Tech, joined the lab. Welcome, Sid! Sid will also perform a CHRB-funded undergraduate research fellowship in the lab this summer.
5/11/2018: Shradha successfully completed her Master's degree in Biochemistry at Virginia Tech. Congratulations!
5/11/2018: Shradha successfully completed her Master's degree in Biochemistry at Virginia Tech. Congratulations!
4/30/2018: Darren won 2018 Translational Obesity Undergraduate Research (TOUR) Scholarship. Congratulations!
4/30/2018: Darren won 2018 Translational Obesity Undergraduate Research (TOUR) Scholarship. Congratulations!
4/27/2018: Another piece of work with Professor Dongmin Liu's group at Human Nutrition Department on a mechanistic study of anti-diabetic natural product accepted for publication in the Journal of Nutritional Biochemistry.
4/27/2018: Another piece of work with Professor Dongmin Liu's group at Human Nutrition Department on a mechanistic study of anti-diabetic natural product accepted for publication in the Journal of Nutritional Biochemistry.
3/30/2018: Shradha won a poster presentation award in the Virginia Tech Graduate Student Assembly annual research symposium. Congratulations!
3/30/2018: Shradha won a poster presentation award in the Virginia Tech Graduate Student Assembly annual research symposium. Congratulations!
3/22/2018: Christopher won 2018 Fralin SURF Fellowship. Congratulations!
3/22/2018: Christopher won 2018 Fralin SURF Fellowship. Congratulations!
1/27/2018: Dr. Xu gave an invited seminar titled "Chemical Biology of Protein Amyloids in Neurodegeneration: Small Molecule Inhibitor Discovery and Mechanisms" in the Department of Chemistry and Biochemistry at the University of Tulsa, Oklahoma.
1/27/2018: Dr. Xu gave an invited seminar titled "Chemical Biology of Protein Amyloids in Neurodegeneration: Small Molecule Inhibitor Discovery and Mechanisms" in the Department of Chemistry and Biochemistry at the University of Tulsa, Oklahoma.
1/20/2018: Allison VanInwegen, a BCHM junior, and Christopher Tan, a BCHM sophomore joined lab. Welcome, Allison and Christopher!
1/20/2018: Allison VanInwegen, a BCHM junior, and Christopher Tan, a BCHM sophomore joined lab. Welcome, Allison and Christopher!
1/5/2018: Dr. Xu and his collaborator, Prof. Dongmin Liu from HNFE won a seed fund from Virginia Tech Center for Drug Discovery to characterize a novel anti-diabetic compound.
1/5/2018: Dr. Xu and his collaborator, Prof. Dongmin Liu from HNFE won a seed fund from Virginia Tech Center for Drug Discovery to characterize a novel anti-diabetic compound.
12/22/2017: Bin co-authored a collaborating paper in Journal of Medicinal Chemistry with Professor Shijun Zhang's group at Virginia Commonwealth University on neuroprotective compounds development for Alzheimer's disease.
12/22/2017: Bin co-authored a collaborating paper in Journal of Medicinal Chemistry with Professor Shijun Zhang's group at Virginia Commonwealth University on neuroprotective compounds development for Alzheimer's disease.
12/16/2017: Paul won 2017 Kendall King award for the most outstanding advanced graduate student in the department. Congratulations!
12/16/2017: Paul won 2017 Kendall King award for the most outstanding advanced graduate student in the department. Congratulations!
12/6/2017: Paul did an outstanding job and successfully defended his Ph.D. dissertation - Well done, Dr. Velander!
11/8/2017: Xu lab hosted departmental seminar speaker, Prof. Xin Zhang from Penn State University on 11/6/2017. Dr. Zhang did an excellent talk on highly innovative work on chemical biology of protein aggregation!
11/2/2017: Shradha was a winner in the Student Poster Session of Virginia Tech Annual Drug Discovery Day: 2017. The title of the poster was "Purification, Characterization, and Cytotoxic Studies of Human Tau Isoforms for Tau Aggregation Inhibitor Discovery". Way to go!
10/28/2017: Dr. Xu gave a seminar in the Department of Medicinal Chemistry at Virginia Commonwealth University School of Pharmacy in Richmond, VA.
10/20/2017: Dr. Xu gave a seminar at the Institute of Materia Medica, Chinese Academy of medical Sciences & Peking Union Medical College in Beijing, China.
9/18/2017: Xu Lab in the news - our olive-related oleuropein work, which was recently published in the journal of Biochemistry, was reported by over 50 national and international (US, UK, France, Spain, Italy, Indonesia etc) news outlets, including well-known sources such as Science Daily, Men's Fitness, EurekAlert! by the American Association for the Advancement of Science (AAAS), and local WFIR AM 960/FM 107.3 from Roanoke, VA. It was a hit!
9/18/2017: Xu Lab in the news - our olive-related oleuropein work, which was recently published in the journal of Biochemistry, was reported by over 50 national and international (US, UK, France, Spain, Italy, Indonesia etc) news outlets, including well-known sources such as Science Daily, Men's Fitness, EurekAlert! by the American Association for the Advancement of Science (AAAS), and local WFIR AM 960/FM 107.3 from Roanoke, VA. It was a hit!
9/10/2017: Darren Dougharty, a BCHM sophomore, and Xedrix Barbeyto, a BCHM freshman joined lab. Welcome, Darren and Xedrix!
9/10/2017: Darren Dougharty, a BCHM sophomore, and Xedrix Barbeyto, a BCHM freshman joined lab. Welcome, Darren and Xedrix!
9/5/2017: Xu lab hosted Virginia Tech Life Science Seminar (VTLSS) speaker, Professor and Dean George Perry, from the University of Texas at San Antonio on 9/1/2017. George's talk and visit was very well received from the faculty and students!
8/25/2017: Xu Lab in Virginia Tech News.
8/22/2017: Ling and Paul's paper "Olive component oleuropein promotes beta-cell insulin secretion and protects beta-cells from amylin amyloid induced cytotoxicity" has been accepted for publication in Biochemistry as a Rapid Report. Congratulations!
8/22/2017: Ling and Paul's paper "Olive component oleuropein promotes beta-cell insulin secretion and protects beta-cells from amylin amyloid induced cytotoxicity" has been accepted for publication in Biochemistry as a Rapid Report. Congratulations!
8/10/2017: Dr. Xu will give an invited speaker lecture at the 6th Annual Conference of the International Chemical Biology Society (www.chemical-biology.org) be held in Shanghai, China in October 17-20, 2017.
8/10/2017: Dr. Xu will give an invited speaker lecture at the 6th Annual Conference of the International Chemical Biology Society (www.chemical-biology.org) be held in Shanghai, China in October 17-20, 2017.
7/28/2017: Congratulations to Frances to be admitted to NIH Postbac program!
7/28/2017: Congratulations to Frances to be admitted to NIH Postbac program!
6/27/2017: Our project on "Drug Repurposing for Tau Aggregation Inhibitors as Neuroprotective Agents for Alzheimer's disease" has been funded by Virginia Center on Aging. Congratulations to Ling to be the PI for this project!
6/27/2017: Our project on "Drug Repurposing for Tau Aggregation Inhibitors as Neuroprotective Agents for Alzheimer's disease" has been funded by Virginia Center on Aging. Congratulations to Ling to be the PI for this project!
6/16/2017: The Commonwealth Health Research Board (CHRB) Grant Award to Xu Lab renewed for the second year. Thanks for everyone who are involved for their wonderful work and productivity!
5/20/2017: Bin won 2017 Virginia Tech Gamma Sigma Delta Teaching Award of Merit.
5/20/2017: Bin won 2017 Virginia Tech Gamma Sigma Delta Teaching Award of Merit.
5/12/2017: Paul was selected as 2017 Outstanding Graduate Student in Biochemistry. Maddie and Frances both graduated with the honor of Exemplary Undergraduate Research in Biochemistry. Congratulations!
5/12/2017: Paul was selected as 2017 Outstanding Graduate Student in Biochemistry. Maddie and Frances both graduated with the honor of Exemplary Undergraduate Research in Biochemistry. Congratulations!
5/10/2017: Shradha has been funded a Translational Obesity Research (TOR) Interdisciplinary Graduate Education Program (IGEP) traineeship for 2017-2018!
5/10/2017: Shradha has been funded a Translational Obesity Research (TOR) Interdisciplinary Graduate Education Program (IGEP) traineeship for 2017-2018!
4/28/2017: Xu lab attended the ASBMB annual meeting in Chicago from April 22-26, 2017. Maddie, Frances, Shradha, and Paul presented posters and participated career developmental sessions. Bin gave an oral talk on "Protein amyloid small molecule inhibitor discovery and mechanisms".
4/28/2017: Xu lab attended the ASBMB annual meeting in Chicago from April 22-26, 2017. Maddie, Frances, Shradha, and Paul presented posters and participated career developmental sessions. Bin gave an oral talk on "Protein amyloid small molecule inhibitor discovery and mechanisms".
4/21/2017: Maddie and Frances both received Ann L. and John L. Hess Undergraduate Travel Award and Paul received an Eheart Graduate Travel Award to attend the American Society for Biochemistry and Molecular Biology annual meeting in Chicago from April 22-26, 2017. Congratulations!
4/21/2017: Maddie and Frances both received Ann L. and John L. Hess Undergraduate Travel Award and Paul received an Eheart Graduate Travel Award to attend the American Society for Biochemistry and Molecular Biology annual meeting in Chicago from April 22-26, 2017. Congratulations!
4/4/2017: Paul's review paper on "Natural Product-Based Amyloid Inhibitors" has been accepted for publication in Biochemical Pharmacology (2015 Impact Factor 5.091). Way to go!
3/18/2017: Dr. Xu has been selected as a speaker at the Southeastern Chemical Biology Symposium to be held in University of Georgia, Athens, GA in April 2017. The theme of the symposium is "Small Molecules for Understanding Life & Managing Disease".
3/12/2017: Dr. Xu has been recognized as Virginia Tech "Teacher of the Week".
2/13/2017: Ling's book chapter on thermogenic adipocyte drug screening has been published!
2/13/2017: Lu's paper "A rapid method for refolding cell surface receptors and ligands" published in the journal of Scientific Reports in 2016 has been recommended in F1000Prime as being of special significance in structural biology field. Way to go!
1/20/2017: Dr. Xu has been selected as a speaker at the annual American Society for Biochemistry and Molecular Biology (ASBMB) symposium in Chicago, IL in April 2017. The title of his talk is "Protein Amyloid Inhibitor Discovery and Mechanisms".
1/20/2017: Dr. Xu has been selected as a speaker at the annual American Society for Biochemistry and Molecular Biology (ASBMB) symposium in Chicago, IL in April 2017. The title of his talk is "Protein Amyloid Inhibitor Discovery and Mechanisms".
1/6/2017: Xu Lab research in Virginia Living News.
1/6/2017: Xu Lab research in Virginia Living News.
12/28/2016: Bin co-authored a collaborating paper in ACS Chemical Biology with Professor Feng Lin's group at the Cleveland Clinic Foundation in immune peptide vaccine research.
12/28/2016: Bin co-authored a collaborating paper in ACS Chemical Biology with Professor Feng Lin's group at the Cleveland Clinic Foundation in immune peptide vaccine research.
12/13/2016: Bin was selected as an Early Career Reviewer (ECR) for grants review at the Study Sections of the Center for Scientific Review, National Institutes of Health (NIH).
12/13/2016: Bin was selected as an Early Career Reviewer (ECR) for grants review at the Study Sections of the Center for Scientific Review, National Institutes of Health (NIH).
11/28/2016: Ling's book chapter "Using thermogenic beige cells to identify biologically active small molecules and peptides" has been accepted in the Methods in Molecular Biology series in the book titled "Thermogenic Fat". Congratulations!
11/28/2016: Ling's book chapter "Using thermogenic beige cells to identify biologically active small molecules and peptides" has been accepted in the Methods in Molecular Biology series in the book titled "Thermogenic Fat". Congratulations!
11/14/2016: Xu lab presented two posters at the annual VT Center for Drug Discovery Poster Session on 11/9. Dr. Xu served as a judge.
11/14/2016: Xu lab presented two posters at the annual VT Center for Drug Discovery Poster Session on 11/9. Dr. Xu served as a judge.
10/22/2016: Xu lab hosted Virginia Tech Life Science Seminar (VTLSS) speaker, Prof. Andrew Herr, from Cincinnati Children's Hospital Medical Center on 10/21/2016. Andy's talk was well received!
10/17/2016: Dr. Xu was invited to serve as a grant reviewer for Oak Ridge Associated Universities / Florida Department of Health Biomedical Research Programs proposals.
10/7/2016: Paul and Bin attended Virginia-Nordic Precision Neuroscience Conference held in Roanoke, VA. Xu lab presented a poster titled "Discovery and mechanisms of small molecule inhibitors against amylin amyloid deposits in the pancreas and the brain".
10/6/2016: Ling and Bin published a collaborating paper in Scientific Reports with Professor Dognmin Liu's group in molecular obesity research.
9/21/2016: Bin has been selected as an Invited IUPHAR Speaker at the joint conference on the Mechanism of Action of Nutraceuticals (ICMAN) and the International Union of Pharmacology (IUPHAR), which will be held in Aberdeen, Scotland, in September 2017. http://www.icman-iuphar-np-2017.org/programme/keynote-speakers/.
9/22/2016: Xu lab hosted Biochemistry Seminar speaker, Prof. Florin Despa, from University of Kentucky on 9/21/2016. It was a great talk and visit!
9/1/2016: Xu Lab in Virginia Tech News.
8/25/2016: Xu Lab was awarded an equipment fund to purchase smart cage system for rodent studies from the State Council of Higher Education for Virginia (SCHEV) via Virginia Tech College of Agriculture and Life Sciences.
8/12/2016: Xu Lab was awarded a research grant titled "Prevention of amylin amyloidosis in type 2 diabetes by botanical baicalein" from Diabetes Action Research and Education Foundation (DAREF). This is a competitive grant renewal.
8/1/2016: Xu lab in the news - The Commonwealth Health Research Board of the State of Virginia made a press release today on grant awards to eleven medical and health researchers in Virginia. Among these eleven groups, Xu lab aims to obtain an understanding of molecular connections between obesity-related type 2 diabetes and the risk for Alzheimer's disease.
http://www.chrb.org/linked_documents/PR_2017_CHRB_Grant_Awards.pdf
8/1/2016: Xu lab in the news - The Commonwealth Health Research Board of the State of Virginia made a press release today on grant awards to eleven medical and health researchers in Virginia. Among these eleven groups, Xu lab aims to obtain an understanding of molecular connections between obesity-related type 2 diabetes and the risk for Alzheimer's disease.
http://www.chrb.org/linked_documents/PR_2017_CHRB_Grant_Awards.pdf
7/19/2016: Paul and Ling's paper "Amylin amyloid inhibition by flavonoid baicalein: key roles of its vicinal dihydroxyl groups of the catechol moiety" has been accepted for publication in Biochemistry as a Rapid Report. Congratulations!
7/11/2016: Paul was awarded an Eheart Travel Award to attend the 30th Anniversary Symposium of the Protein Society in Baltimore, MD from July 16-19, 2016. Congratulations, Paul!
6/30/2016: Bin was invited to serve as a reviewer for the journal of "Scientific Reports".
6/25/2016: Dr. Xu was invited to give a seminar talk at Shanghai Institute of Materia Medica, Chinese Academy of Sciences on June 20, 2016. The title was "Discovery and mechanisms of natural product inhibitors against amylin amyloidosis in type 2 diabetes and neurodegeneration".
6/15/2016: Dr. Xu was invited to be a grant reviewer for the Alzheimer's Association.
6/7/2016: Dr. Xu was invited to be a grant review panelist for the Alzheimer's and Related Diseases Research Award Fund (ARDRAF) from Virginia Center on Aging.
5/25/2016: Dr. Xu attended Virginia BrainRx: a Symposium on Drug Discovery for the Brain and presented the work titled "Discovery and mechanisms of small molecule inhibitors against amylin amyloidosis in the pancreas and the brain".
5/18/2016: Xu Lab was awarded a research grant titled "Molecular mechanisms of amylin as a novel contributor to Alzheimer's disease" from the Commonwealth Health Research Board (CHRB).
5/3/2016: Lu and Ling's paper "A Rapid Methods for Refolding Cell Surface Receptors and Ligands" has been accepted for publication in Scientific Reports (2015 Impact Factor 5.228. Congratulations!
3/30/2016: Bin was invited to give a talk at the 12th Sino-US Chemistry and Chemical Biology Professors Conference at Sun Yat-Sen University from June 23-25, 2016 in Guangzhou, China.
1/5/2016: Katherine Kate, a BCHM sophomore, joined lab. Welcome, Kate!